Nanotoxicology - Interactions of Nanomaterials with Biological Systems


Edited by
Yuliang Zhao and Hari Singh Nalwa

    June 2006
500 pages, Hardcover
ISBN: 1-58883-088-8

With the rapid development of nanotechnology and its applications, a wide variety of nano-structured materials are now used in commodities, pharmaceutics, cosmetics, biomedical products, and industries. While nanoscale materials possess more novel and unique physicochemical properties than bulk materials, they also have an unpredictable impact on human health. The entrance into and interaction of nanomaterials in the human body have generated intense scientific curiosity, attracting much attention as well as increasing concern from the public, nanomaterial-based industries, academia, and governments worldwide. Nanotoxicology is the first textbook in this multidisciplinary area to address all those points and, thus, fill the knowledge gap concerning risks from nanotechnology, the impact of nanomaterials on the human body, their interactions with biological systems, and their risk assessments. The book comprises 16 review chapters covering the main aspects of dealing with the risk of exposure to nanomaterials. In addition, the text summarizes the toxicological effects and biological properties (in vitro or in vivo) for a very wide variety of man-made nano-structured materials including: metallic nanoparticles, metal oxide nanoparticles, dendrimers, quantum dots, nanoclusters, nanocrystals, nanowires, fullerenes, fullerene-based derivatives, single- and multi-wall carbon nanotubes, functionalized carbon nanotubes, polymer nanoparticles, carbon black, nano-coatings, nanomedicines, and others. In addition to covering the toxicological aspects of recognition, identification, and quantification of hazards resulting from human exposure to various types of nanomaterials during manufacturing and applications, this book also outlines possible medical and therapeutic benefits of nanomaterials for clinical diagnosis, drug delivery, disease treatment, and physiological and immunological mechanisms. Nanotoxicology is aimed at providing up-to-date information on the potential toxicological effects, risk assessment, and safety evaluation of nano-structured materials on human healthfor a wide audience, including those working in the fields of nanoscience and nanotechnology, biology, toxicology, chemistry, chemical biology, medical sciences, public health sciences, standardization of nanotechnology (nano-safety standards) as well as for policy makers developing regulatory frameworksin government departments and nanotechnology industries/enterprises. The book also offers special features that make it useful to general readers interested in health issues concerning nanomaterials and safe nanotechnology. Unique and especially valuable are the book’s strategies on how to reduce or eliminate nanotoxicological effects and a multidisciplinary methodology for testing all materials on the nanoscale to evaluate the potential for human exposure.

(1) Biological Activities of Nanomaterials/Nanoparticles
(2) Interactions between Nanoparticles and Living Organisms: Mechanisms and Health Effects
(3) Interactions of Nanoparticles with Cells and Their Cellular Nanotoxicology
(4) Cytotoxicity of Ultrafine Particles
(5) Uptake and Cytotoxicity of Nanoparticles
(6) Carbon Nanoparticles: Benefits and Risks for Human Health
(7) Cellular Responses to Nanoparticle Exposure
(8) Cytotoxicity and Potential Mechanism of Nanomaterials
(9) Pharmaceutical Developments Based on Cytotoxicity of Nanoparticles: Supramolecular Strategies and Study of Biological Interactions
(10) Interactions of Nanoparticles with Biomolecules and Their Molecular Nanotoxicology
(11) Nanoparticle Effects on the Immune System
(12) Toxicology of Carbon Nanomaterials
(13) The Biocompatibility of Nanoparticles
(14) Methodology for Nanotoxicology
(15) Dependence of Nanotoxicity on Nanoscale Characteristics and Strategies for Reducing and Eliminating Nanotoxicity
(16) Nanoparticle Toxicology and Ecotoxicology: The Role of Oxidative Stress

This book is a very valuable reference source for scientists, research professionals working in R&D laboratories, students, college and university professors working in the field of nanotoxicology, a highly active area of research dealing with the potential toxicological effects, risk assessment, and safety evaluation of nanostructured materials on the human health. The book is intended for a broad audience working in the fields of toxicology, chemistry, materials science, environmental science, physics, engineering, industrial toxicology, toxicological testing, cellular toxicology, cancer research, cell biology, health sciences, chemical and molecular biology, bioinformatics, pharmacology, nanomedicine, nanomaterials based therapeutic drug monitoring, pharmaceutics, cosmetics, and biological sciences.

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