Cancer Hallmarks
ISSN: 2165-428X (Print); EISSN: 2165-4298 (Online)
Copyright © 2000- American Scientific Publishers. All Rights Reserved.

  Instructions for Authors
  The journal "Cancer Hallmarks" publishes important studies demonstrating significant discoveries within the field of hallmarks of cancer that are manifested in cancer diseases. The multidisciplinary journal is focused on publishing original research articles, reviews, rapid communications and opinions on the hallmarks of cancer for a broad audience spanning from basic to clinical to epidemiological research in oncology. Cancer therapeutic research related with correcting the dysregulation in the hallmarks of cancer is also covered. The following fields of the hallmarks of cancer are covered.
(1) Growth of cancer cells;
(2) Resistance to inhibitory signals that regulate cancer cell growth;
(3) Resistance to programmed cell death (Apoptosis);
(4) Stimulating the growth of new blood vessels for formation of tumors (Angiogenesis);
(5) Limitless capability to replicate forever;
(6) Invasion of local tissues and spreading to distant organs (Metastasis);
(7) Escaping immune surveillance;
(8) Cancer inflammation;
(9) Cancer genome instability; and
(10) Dysregulated energy metabolism.
  JOURNAL POLICY: It is journal policy to publish only 100% original and unpublished research work therefore Cancer Hallmarks does not wish to receive any papers on research work that has already been reported in parts or contains already published text, data, figures, tables or other illustrations or any copyright materials whatsoever that has been submitted or accepted for publication either in a journal or conference proceedings elsewhere in any form, in print or in electronic media. When submitting a manuscript, authors should make a full statement to the Editors that the research work contained in their manuscript is completely original and unpublished. If redundant or duplicate publication is attempted or occurs authors should expect immediate editorial action to be taken including prompt rejection of the submitted manuscript. Submission of any manuscript that contains redundant or duplicate publication of the same or very similar research work violates the policies of this journal.

It is the sole responsibility of all authors to ensure that all manuscripts are new, original and not published previously in any form any media, shall not infringe upon or violate any kind of copyrights of others and does not contains any plagiarized, fraudulent and improperly attributed materials. Extended and modified versions of previously published abstracts, papers in any conference or journal are not allowed whatsoever.

Corresponding author should provide a clear statement confirming this while submitting manuscript to any ASP journal. Is this manuscript 100% original and unpublished? Has this manuscript been published in parts (figures/text/tables) in any conference proceedings or journal in any media or language or format whatsoever? Is this manuscript from free from plagiarism (including self-plagiarism) and copyright infringement?

Authors must follow this "Journal Policy" strictly.

PUBLISHING ETHICS: American Scientific Publishers strictly follows guidelines set by the Committee on Publication Ethics (COPE), Code of Conduct and Best Practice Guidelines for Journal Editors, available at All Authors, Peer-Reviewers and Editors work together in a great harmony to ensure the highest ethical standards in publishing quality research work in our journals.

ETHICAL COMPLIANCE: Research papers reporting animal or clinical studies should, where appropriate, contain a statement that they have been carried out with animal or human ethics committee approval. All scientific studies should be carried out in accordance with the relevant national and local guidelines. Each author(s) warrants that his or her research institution has fully approved the protocol for all scientific studies involving animals or humans and that all experiments of any kinds were conducted in compliance with ethical and humane principles of research after ethics committee approval.

An Open Access Journal
Cancer Hallmarks is an open-access journal, published both in print and online editions. The online edition of this journal is freely available from our website to its readers throughtout the world.

Manuscript-Processing Fees
Open access publishing is not without any production and editorial costs; therefore, it is financed by manuscript-processing fees, to be paid by the authors or their affiliated research institutions. To pay occurring expenses associated with manuscript processing, production, editorial, typesetting, printing, web-hosting, and archiving, authors are required to pay US$200 per journal page. However there are no charges for color figures/illustrations for research articles published electronically. The payment of manuscript-processing fees is necessary to maintain worldwide open-access to the all contents of this journal. This also allows authors' self-archiving and distribution of their published research work. Publisher will issue an invoice of manuscript-processing fees after a manuscript is accepted for publication. Online submission of the manuscript to the journal can be completed after the manuscript-processing fees have been agreed by authors. Accepted peer-reviewed manuscripts will not be processed and forwarded to production until all publication charges are paid in full to the publisher prior to publication. The publication charges for authors from low-income countries can be waived. The manuscript-processing fees are also waived for authors whose institutes subscribe to this journal.

Hardcopy of Journal Issue
If authors require a hardcopy of the journal issue having their research article then authors should pay additional $750 to recover the costs of all color illustrations in a print edition. No free hardcopies of journal issue are provided.
  SUBMISSION OF MANUSCRIPT: Authors are kindly advised to read Cancer Hallmarks policy and also the uniform requirements for manuscripts submitted to Biomedical Journals as proposed by the International Committee of Medical Journal Editors ( before submitting their manuscript to Editors. Authors are encouraged to submit high quality original research work that has not been published or nor under consideration by other journals or conference proceedings elsewhere. Authors should submit manuscript online.
  (1) Submission Preparation
Authors should submit a list of FIVE (5) potential referees accompanied with their complete mailing address, phone, fax and email address, who may be contacted for reviewing the manuscript though refereeing, is done by anonymous reviewers. In order to ensure that the highest quality manuscripts are published, reviewing process is carried out in two stages. A mandatory editor's approval is required in the first stage for the manuscripts before it is submitted to the peer review process in the second stage. To speed up the reviewing process, editors will communicate with authors and the referees via email. ASP or Editors will not return manuscripts to authors and keep any records whatsoever after a formal decision has been made about the manuscript. Editors have the right to reject the manuscript.
  (2) Instructions for the Manuscript Preparation
Cover Letter
Authors should include a cover letter which summarizes the important and significant discovery of the studies. A cover letter may suggest proper reviewers or request reviewer exclusions. The cover letter will be kept confidential and will not be seen by manuscript reviewers.
  Article Organization
Manuscripts will include the following sections:

The title should deliver the main point of the paper.
A single paragraph contains fewer than 200 words. The goal of the abstract is to provide a brief background of cancer hallmark dysregulation question and describe the significance of the experimental results. No reference citation in the abstract.

Hallmarks impact
The Hallmarks impact should be a single paragraph contains fewer than 120 words to describe the impacts on cancer hallmarks. The purpose of this section is to put the relevance of author's work in perspective for potential cancer treatment strategy design.

Include 5 key words

The Introduction should present the importance of present studies in providing significance to answer previously unresolved question.

The Results should present concise data logically. Use divided subheadings to establish the logical sequence.

The Discussion should be brief and comprehensive. Emphasis should be on the discussing the novelty of the studies and establishing a new hypothesis or model on the basis of the studies.

Materials and Methods
Information of materials and method should be described in order to be clear to the readers for understanding the data presentation in the paper. Extra information can be included in supplemental section.

List of funding resources can be listed.
These should be brief and placed at the end of the text before the references.

References should be in the proper format on a separate page, numbered in the sequence in which they occur in the text. Cite references numerically as superscripts in the text and list at the end of the manuscript. Do not use abstracts and websites as references. References to papers accepted but not yet published should be designated as "in press". Information from manuscripts submitted but not accepted should be cited in the text as "unpublished observations" with written permission from the source. Avoid citing a "personal communication" unless it provides essential information not available from a public source. For scientific articles, authors should obtain written permission and confirmation of accuracy from the source of a personal communication. References should be listed in the following style. The references must be verified by the authors against the original documents.
  1. Journal article
Yokoyama, A., and Cleary, M. L. (2008). Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell 14, 36-46.

2. Book
Nalwa H.S., Editor, (2005), Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, Vol. 1-2, American Scientific Publishers, Los Angeles.

3. Chapter in a Book
Schalkhammer T, (2004), Bionanodevices, in Encyclopedia of Nanoscience and Nanotechnology, Edited by Nalwa H.S., American Scientific Publishers, Los Angeles, Vol. 1, pp.329-360.

4. Conference Proceedings
Kimura, J. and Shibasaki, H., Editors (1995), Recent advances in clinical neurophysiology. Proceedings of the 10th International Congress of EMG and Clinical Neurophysiology, October 15-19; Kyoto, Japan

5. Conference Paper
Bengtsson S, Solheim B. G. (1992), Enforcement of data protection, privacy and security in medical informatics. In: Lun KC, Degoulet P, Piemme TE, Rienhoff O, editors. MEDINFO 92. Proceedings of the 7th World Congress on Medical Informatics; 1992 September 6-10; Geneva, Switzerland. North-Holland, Amsterdam; pp.1561-1565.

6. Scientific Report
Field M. J., Tranquada R.E., Feasley J. C., editors (1995), Health services research: work force and educational issues. Washington: National Academy Press; Contract No.: AHCPR282942008. Sponsored by the Agency for Health Care Policy and Research.

7. Dissertation
Kaplan S.J. (1995), Post-hospital home health care: the elderly's access and utilization [dissertation]. St. Louis (MO): Washington University.

8. Patent
C. E. Larsen, R. Trip, and C.R. Johnson, Methods for procedures related to the electrophysiology of the heart. U.S. Patent 5,529,067, Jun 25 (1995).
  Do not use the phrases "et al." and "ibid." in the references in the reference section Instead the names of all authors in a reference must be listed.

It is very important to supply high quality figures in a form suitable for reproduction. Each figure must be referred to in the text. Figure labels should be set in uppercase Helvetica or Arial fonts. Authors are advised not to include separate panels on multiple pages.

Authors are advised to use the Microsoft Word table function. Tables should include a title, footnotes , and legend. Tables are to be submitted as a separate section.

Supplemental Information
Authors are advised to submit Supplemental information that will provide additional protocol or data information to the original submission.

All manuscripts must be in English, typed double-spaced on one side of the page throughout (including footnotes, references, tables, legends) on 8.5" x 11" or A4 white paper leaving at least 1 inch left hand margin.

Internationally accepted units of measurement must be used. The units of measurement are used in conjunction with their numerical values; the units should be abbreviated as suggested below. If more commonly used units are adopted, conversion factors should be given at their first occurrence. Greek symbols may be used.
%, ºC, nm, !m (not m), mm, cm, cm3, m, h (or hr), min, s (or sec), !g, mg, g (or gm), kg, cal, kcal, in. (or write out inch), ml [write out liter(s)].

No abbreviations are allowed in the title and abstract and should be defined the first time they are used within the text. The "Cancer Hallmarks" should be abbreviated as Cancer Hallmarks for the citation purpose.

(3) Formats for Online Submission
Authors are advised to convert all text/figures/tables from Microsoft Word, Excel, or PowerPont formats to a single PDF file and submit the manuscript as a single file in a PDF format. All submitted figure images must have resolutions of at least 300 dpi.

Authors are advised to use these formatting guidelines. Manuscripts that do not follow the preparation guidelines may be returned to the authors.

(1) COMMUNICATIONS: Highest priority will be given to the communications reporting important new scientific and technological findings. Rapid publication is provided for concise and up-to-date reports. These articles should not exceed three-four published pages. No section headings should be used for these short communications.

(2) RESEARCH ARTICLES: Full length papers that report original research work on new ideas in the field of cancer hallmark dysregulation.

(3) REVIEWS: The state-of-the-art review articles are limited to a maximum length of 35 journal pages having more than 100 references. It is authors' responsibility to obtain written copyright permissions to reproduce any copyright materials from other sources. Authors are advised to cite proper references in figure/tables captions of all previously published figures/tables/illustrations including their own published work and obtain copyright permissions from appropriate publishers and authors.

COVER ART: Cancer Hallmarks features new cover art time to time. Authors are encouraged to submit high quality color figure/illustration to have their published paper featured.

MANUSCRIPT PROCESSING FEES: Authors should understand that there are many occurring publishing expenses per journal page associated with manuscript processing, editorial, production, typesetting, printing, paper, binding, shipping, web-hosting, and archiving. However authors pay no publication fees as well as the costs of any color figure/illustration in a print edition to American Scientific Publishers whatsoever, therefore, publisher is doing all services to authors free of costs and/or at fractional costs, hence, publisher is not obligated to provide any hard/softcopies of journal issue and/or research article to anyone whatsoever. Authors may download pdf file of their published papers from Ingenta after paying fractional costs. If authors require a hardcopy of the journal issue having their research articles then authors may also purchase hardcopies of the journal issue or subscribe to the journal by contacting the publisher. No free hard/softcopies of journal issue and/or research article are provided. On the other hand, if authors want to support the journal by paying full manuscript processing fees plus all costs of color figures/illustrations/photos in a print edition through their research grants or affiliated institutions, then publisher will provide hardcopy of journal issue or pdf file of his/her research article after receiving a full payment. American Scientific Publishers highly appreciate for author's kind understanding and support.

FREE COLOR Figures for Online Edition: Color illustrations are most welcome by the journal as they are effective in conveying complex.

PROOFS: Page proofs for the correction of printer's errors only will be dispatched to the corresponding author denoted with an asterik (*) unless otherwise requested. Alterations at this stage are not allowed as they are expensive and may have to be charged to the authors. The proofread copy and reprint order form must be returned within 72 hours.

OFFPRINTS: Authors may order offprints of articles with a minimum of 100 from American Scientific Publishers (ASP) prior to publication. An order form accompanying the page proofs will be sent directly to the corresponding author (*). Please return your offprint order form with the page proofs.

WARRANTIES AND COPYRIGHTS: By submitting the manuscript, the authors warrant that the entire work is original and unpublished; it is submitted only to this Journal and all text, data, figures/tables or other illustrations included in the research article are completely original and unpublished, and these have not been previously published or submitted elsewhere in any form or media whatsoever. All authors are responsible for the complete contents of their manuscript. The author(s) warrant that the work contains no unlawful or libelous statements and opinions and liable materials of any kind whatsoever, do not infringe on any copyrights, intellectual property rights, personal rights or rights of any kind of others, and does not contains any plagiarized, fraudulent, improperly attributed materials, instructions, procedures, information or ideas that might cause any harm, damage, injury, losses or costs of any kind to person or property. Each author(s) agrees to defend, indemnify, and hold harmless American Scientific Publishers and the Editors for any breach of such warranties. It is authors' responsibility to obtain written copyright permissions from other sources (publishers) for reproduction of any figures, tables, photos, illustrations, text or other copyright materials from previously published work. It is the policy of American Scientific Publishers to own the copyright of all contributions it publishes. To comply with the U.S. Copyright Law, a Copyright Transfer Form that transfer copyright of the article to the publisher must be completed by the authors prior to publication of an accepted article in this journal. Authors must submit a signed copy of the Copyright Transfer Agreement with their manuscript.

ETHICAL ISSUES: Authors cannot submit a manuscript for publication to other journals simultaneously. It is waste of valuable resources because editors and referees spent a great deal of time processing submitted manuscripts. It is also unethical to republish similar research articles (text/figures/tables) again because journals have limited page space and it most likely violates copyrights which have already been transferred to the first journal. Therefore, all journals require a signed author's copyright transfer agreement stating the originality of the research work submitted through a manuscript. As stated above that authors should submit original, new and unpublished research work to the journal. The ethical issues such as plagiarism, fraudulent and duplicate publication, violation of copyrights, authorship and conflict of interest are serious issues concerning ethical integrity when submitting a manuscript to a journal for publication.

WITHDRAWAL OF MANUSCRIPTS: If the author requests withdrawal of manuscript after submission within the time span when the manuscript is still in the peer-reviewing process with Editors/Referees, author is allowed to withdraw the manuscript without paying any withdrawal penalty whatsoever. However, it is unethical to withdraw a submitted manuscript from one journal if accepted by another journal. The withdrawal of manuscripts from the journals after submitting to the publisher will incur a withdrawal penalty from American Scientific Publishers. After the manuscript is accepted for publication either through journal editors or guest editors or conference organizers, the withdrawal is not permitted by American Scientific Publishers. If the authors or conference organizers or a third party withdraw manuscripts any time after final manuscripts have already been submitted to American Scientific Publishers for processing, the request is not entertained without a significant withdrawal penalty. Authors or conference organizers or a third party are not allowed to withdraw submitted manuscripts because the withdrawal wastes valuable manuscript processing time, money and works invested by the publisher. The authors or conference organizers or a third party must always pay $200 per page manuscript processing charges as withdrawal penalty to the publisher even if the withdrawal is permitted. The withdrawal of the conference papers by conference organizers will never be permitted and the conference organizers will be punished for withdrawal by paying a withdrawal penalty of US$500 per manuscript. Withdrawal of manuscripts is only allowed after withdrawal penalty has been fully paid to the American Scientific Publishers by the authors or conference organizers or a third party. Any reason whatsoever of withdrawal of submitted manuscripts is treated as invalid and completely unacceptable under any circumstances. Publisher is not responsible for any damages whatsoever resulting from this consequence of the author's or conference organizer's or a third party decision. All questions or differences whatsoever concerning manuscripts withdrawal from American Scientific Publishers whether as to construction or otherwise, shall be held in the County of Los Angeles, California, United States of America.

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