ISSN: 2167-955X (Print); EISSN: 2167-9568 (Online)
Copyright © 2000- American Scientific Publishers. All Rights Reserved.
|Instructions for Authors|
|The MESSENGER is an international
peer-reviewed journal, focused on all aspects of messenger-signaling.
Cells are surrounded by a plasma membrane, which isolates them from the
environment and, in so doing, defines their existence. How cells can
respond to a wide range of hormones, or first messengers, that cannot
cross the plasma membrane had puzzled generations of scientists. During
the 1950s, Earl W. Sutherland advanced the concept of second messenger
to account for the intracellular responses to membrane impermeant
hormones and the field of cellular signal transduction was born. The
impact of the concept is pervasive and has led to a host of fundamental
discoveries, including the protein kinase cascades that control
essentially all aspects of cellular regulation. In 1971, Earl W.
Sutherland received the Nobel Prize in Physiology or Medicine for his
discoveries on the mechanisms of hormone epinephrine action and the
second messenger cyclic adenosine monophosphate (cAMP). Since then, only
a limited number of other second messengers have been discovered,
including cyclic guanosine monophosphate (cGMP), inositol trisphosphate
(IP3), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide
phosphate (NAADP). The last three second messengers signal via
mobilization of intracellular stores instead of the protein
phosphorylation. Together, these second messengers regulate the vast
majority of cellular functions. The journal, MESSENGER, is devoted to
all aspects of messenger-signaling, from the upstream activation of the
receptors of the first messengers to the downstream signaling cascades.
Undoubtedly, more novel second messengers will be discovered, expanding
the scope of the journal appropriately. The MESSENGER publishes review
articles, full research articles and short communications of important
new scientific findings on all research aspects of messengers. Review
articles should include comprehensive, critical and up-to-date
information on a particular research topic related to messengers, with
author's photo and short biography. The peer-reviewed proceedings of
scientific meetings, symposia and workshops related to messengers are
also published. Authors will receive the following benefits:
The MESSENGER readership includes international scientists, academic researchers, and medical professionals with research interests in all aspects of messenger-signaling in the fields of molecular and cell biology, physiology, biochemistry, endocrinology, neuroscience, biomedicine, oncology, immunology, microbiology, protein and lipid science, biological chemistry, drug delivery, nanotechnology, pharmacology, toxicology and developmental biology.
|JOURNAL POLICY: It is MESSENGER policy to publish only original and unpublished research work, therefore, the journal does not wish to receive any papers on research work that has already been reported in parts or contains already published text, data, figures, tables or other illustrations or any copyright materials whatsoever that has been submitted or accepted for publication either in a journal or conference proceedings elsewhere in any form, in print or in electronic media. MESSENGER will publish any research article that is technically sound, ethically and appropriately reported, and has conclusions supported by the data. The journal would not make any publication judgment based on the broad interest or importance of the research paper.When submitting a manuscript, authors should make a full statement to the Editors that the research work contained in their manuscript is completely original and unpublished. If redundant or duplicate publication is attempted or occurs authors should expect immediate editorial action to be taken including prompt rejection of the submitted manuscript. Submission of any manuscript that contains redundant or duplicate publication of the same or very similar research work violates the policies of this journal. Extended/modified versions of previously published abstracts/papers in any conferences/journals are not allowed whatsoever. It is the sole responsibility of Authors to ensure that all manuscripts are new, original and not published previously in any form any media, shall not infringe upon or violate any kind of copyrights of others and does not contains any plagiarized, fraudulent and improperly attributed materials. Authors must follow the "Journal Policy" strictly.|
|ETHICAL COMPLIANCE: Research papers reporting animal or clinical studies should, where appropriate, contain a statement that they have been carried out with animal or human ethics committee approval. All scientific studies should be carried out in accordance with the relevant national and local guidelines. Each author(s) warrants that his or her research institution has fully approved the protocol for all scientific studies involving animals or humans and that all experiments of any kinds were conducted in compliance with ethical and humane principles of research after ethics committee approval.|
|SUBMISSION OF MANUSCRIPT: Authors are kindly advised to read MESSENGER policy and also the uniform requirements for manuscripts submission. Authors are encouraged to submit high quality original research work that has not been published or nor under consideration by other journals or conference proceedings elsewhere. Authors should submit manuscript online to the Manuscript Tracking System|
|Authors should submit a List of FIVE (5) potential referees accompanied with their complete mailing address, telephone, fax and email address, who may be contacted for reviewing the manuscript though refereeing, is done by anonymous reviewers selected by the Editor-in-Chief.|
|COVER ART: Authors are encouraged to submit high quality color figure/illustration to have their published paper featured.|
|COMMUNICATIONS: Highest priority will be given to the communications reporting important new scientific and technological findings. Rapid publication is provided for concise and up-to-date reports. These articles should not exceed three-four published pages. No section headings should be used for these short communications.|
|RESEARCH ARTICLES: Full length
papers that report original research work on new ideas in any fields of
science, engineering and medicine.
REVIEW ARTICLES: The state-of-the-art review articles with author's short biography and photo are published. Reviews are limited to a maximum length of 25-30 journal pages (80-100 manuscript pages) having more than 100 references. It is authors' responsibility to obtain written copyright permissions to reproduce any copyright materials from other sources. Authors are advised to cite proper references in figure/tables captions of all previously published figures/tables/illustrations including their own published work and obtain copyright permissions from appropriate publishers and authors.
TYPING: All manuscripts must be in English, typed double-spaced throughout (including footnotes, references, tables, legends) on 8.5" x 11" or A4 white paper leaving at least 1 inch left hand margin.
|INTRODUCTORY MATERIAL: The first page of the manuscript should have a concise title limited to about 15 words and the names of all authors, complete mailing address for correspondence, telephone, fax numbers and email address. Please indicate with an asterisk (*) the author to whom correspondence regarding the manuscript should be directed.|
|ABSTRACT: All manuscripts must contain an informative 350 words abstract explaining the essential contents of the work, key ideas and results.|
|FIGURES: It is very important to supply
high quality figures in a form suitable for reproduction. All figures,
tables, illustrations, photographs should be prepared in such a way that
they could be printed in a single column size with a width of 3 1/4
inches or 8.25 cm. Use 14 ARIAL BOLD font for legends and 11
ARIAL font for numbering/wordings in figures, use the same font for
all figures. Only if absolutely necessary should figures/tables/photos
occupy double columns. Each figure must be referred to in the text and
will be printed in black and white unless otherwise instructed by the
authors. Each Figure should be submitted on a separate sheet and marked
with the name of the author, title of manuscript and figure number. All
formulae and figures should be carefully drafted and never drawn
freehand. High quality original figures and glossy prints of all
photographs are required. Photocopies of the figures and photographs are
not acceptable. High-resolution (600 dpi and better) images are required
for production. All figures should be provided in high-resolution.
Publisher will not do any additional artwork, redrawing or typesetting
FIGURE CAPTIONS: Figure legends should be provided on a separate manuscript page. All abbreviations and symbols used in the figures should be explained, except for standard abbreviations or otherwise previously defined in the preceding text.
|FREE COLOR PRINTING: Color illustrations are most welcome by the journal as they are effective in conveying complex images, graphs and photographs. Free color printing at the publisher's discretion, will provide an opportunity to publish color figures/illustrations in online and print edition at NO COST to the authors. Therefore authors are encouraged to submit illustrations in color where ever necessary for their scientific significance.|
|PHOTOGRAPHS: Half-tone illustrations should be supplied as clear, glossy, unmounted prints. The author's name, title of manuscript and figure number should be written on the back.|
|TABLES: Each table must be referred to in the text. Each table should be typed double-spaced on a separate sheet and identified sequentially by Arabic numerals corresponding to the order in which they appear in the text. Each table should have a brief explanatory title, which should be labeled unambiguously. The position of each table should be clearly marked in the text.|
|UNITS: Internationally accepted units of measurement must be used. The units of measurement are used in conjunction with their numerical values; the units should be abbreviated as suggested below. If more commonly used units are adopted, conversion factors should be given at their first occurrence. Greek symbols may be used.|
|%, ºC, nm, µm (not m), mm, cm, cm3, m, h (or hr), min, s (or sec), µg, mg, g (or gm), kg, cal, kcal, in. (or write out inch), ml [write out liter(s)].|
|The Medline style guide can be used as a general reference on matter of units, grammar and formatting.|
|ABBREVIATIONS: No abbreviations are allowed in the title and abstract and should be defined the first time they are used within the text. The "MESSENGER" should be abbreviated as Messenger the reference citation purpose.|
|FORMATS FOR ONLINE SUBMISSION:
Authors are advised to convert all text/figures/tables from Microsoft Word, Excel, or PowerPont formats to a single PDF file and submit the manuscript as a single file (title/affiliations/abstarct/keywords/text/references/figures/tables) in a PDF format. All submitted figure images must have resolutions of at least 300 dpi.
|Authors are advised to use these formatting guidelines. Manuscripts that do not follow the preparation guidelines may be returned to the authors.|
|ORGANIZATION OF MANUSCRIPT:
The manuscript should be organized in the following sequence and submitted as a single file.
The title should be brief, precise and informative to deliver the main objective of the research paper.
Complete affiliations of all authors of a research paper are required including their department, university/company, city, zipcode, and country.
A single paragraph contains fewer than 350 words. The goal of the abstract is to provide a very brief background of research work accomplished and reporting of significant experimental results. No reference citation in the abstract.
Include 5-6 important keywords related to research topic.
The Introduction should present the importance of present studies in providing significance to answer previously unresolved question.
MATERIALS AND METHODS:
Information of materials and method should be described in order to be clear to the readers for understanding the data presentation in the paper. No supplemental section allowed, make all extra information a part of manuscript.
The results should present concise data logically. Use divided subheadings to establish the logical sequence if necessary.
The discussion should be brief and comprehensive. Emphasis should be on the discussing the novelty of the studies and establishing a new hypothesis or model on the basis of the studies.
Summarize all important accomplishments achieved.
CONFLICT OF INTEREST:
Authors should state if there is any conflict of interest whatsoever. If there is none then authors should write "There is no conflict of interest". In case, no information was provided by authors whatsoever then by signing the Copyright Transfer Agreement, authors agree that publisher is allowed to include "The authors declared no conflict of interest".
List of funding resources can be listed. These should be brief and placed at the end of the text before the references.
LIST OF ABBREVIATIONS:
All abbreviations used in the abstract/text should be defined where first used, or a list of abbreviations may be included in the end before references. Do not use abbreviations in the research paper's title.
|REFERENCES AND NOTES:
All references should be in the proper format on a separate page and written by author's name and year in an order [Lee, 1993] in the text and list in the alphabetical order in the reference section. Do not use abstracts and websites as references. References to papers accepted but not yet published should be designated as "in press". Information from manuscripts submitted but not accepted should be cited in the text as "unpublished observations" with written permission from the source. Avoid citing a "personal communication" unless it provides essential information not available from a public source. For scientific articles, authors should obtain written permission and confirmation of accuracy from the source of a personal communication. Journal title should be used in abbreviations. The full journal title and their abbreviations can be found at http://www.bioscience.org/atlases/jourabbr/list.htm. The references should be arranged in an alphabetical order (authors, years if same authors are repeated) at the end of text. The title of research article should be included in the reference, journal title should be given in italics. The references must be verified by the authors against the original documents. References should be listed in the following style.
1. Journal Articles
Lee, H.C. (1993). Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose. J. Biol. Chem. 268, 293-299.
Lee, H.C. (1997). Mechanisms of calcium signaling by cyclic ADP-ribose and NAADP. Physiol. Rev. 77, 1133-1164.
Yokoyama, A. and Cleary, M.L. (2008). Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell, 14, 36-46.
2. Book Reference
Nalwa, H. S., Ed. (2005). Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, Vol. 1-2, (Los Angeles, USA: American Scientific Publishers).
3. Chapter in Edited Book
Schalkhammer, T. (2004). Bionanodevices. In: Encyclopedia of Nanoscience and Nanotechnology, vol. 1, H. S. Nalwa, Ed. (Los Angeles, USA: American Scientific Publishers), pp.329-360.
4. Conference Proceedings
Kimura, J. and Shibasaki, H., Eds. (1995). Recent advances in clinical neurophysiology. Proceedings of the 10th International Congress of EMG and Clinical Neurophysiology, October 15-19; Kyoto, Japan.
5. Conference Paper
Bengtsson, S. and Solheim, B.G. (1992). Enforcement of data protection, privacy and security in medical informatics. In: MEDINFO 92. Proceedings of the 7th World Congress on Medical Informatics; K. C. Lun, P. Degoulet, T. E. Piemme, and O. Rienhoff, Eds. 1992 September 6-10; Geneva, Switzerland. (Amsterdam; Netherlands: North-Holland). pp.1561-1565.
Field, M.J., R. E. Tranquada, R.E., and Feasley, J.C., Eds. (1995). Health services research: work force and educational issues. Contract No.: AHCPR282942008. Sponsored by the Agency for Health Care Policy and Research (Washington, USA: National Academy Press)
Kaplan, S.J. (1995). Post-hospital home health care: the elderly's access and utilization [dissertation]. Washington University (St. Louis, USA).
Larsen, C.E., Trip, R. and Johnson C.R. (1995). Methods for procedures related to the electrophysiology of the heart. U.S. Patent 5,529,067, Jun 25.
The names of all authors must be included in a reference. Do not use the phrases "et al." and "ibid." in the reference section. Do not use "website address" as a reference. Journal abbreviations should follow the MEDLINE style.
|PROOFS: Page proofs for the correction of printer's errors only will be dispatched to the corresponding author denoted with an asterik (*) unless otherwise requested. Alterations at this stage are not allowed as they are expensive and may have to be charged to the authors. The proofread copy and reprint order form must be returned within 72 hours.|
|OFFPRINTS: Authors may order offprints of articles with a minimum of 100 from American Scientific Publishers (ASP) prior to publication. An order form accompanying the page proofs will be sent directly to the corresponding author (*). Please return your offprint order form with the page proofs.|
|ELECTRONIC SUBMISSION: Upon acceptance of
the manuscript for publication, authors should submit to the publisher a
single file in MS WORD format
containing the final version of the manuscript with a signed Copyright
Transfer Agreement. The preferred medium is Windows/MS-DOS or Macintosh
having MS Word file or TeX. We are also able to accept line
artwork/graphics if you supply us the source files to enables us to
modify the artwork as required for the journal format.
NIH FUNDED RESEARCH:
The authors of research articles related to NIH grants have the right to provide a copy of the final manuscript to NIH after manuscript acceptance for publication for public archiving in PubMed Central which is 12 months after publication in MESSENGER. Please note that only the accepted author's final version of the manuscript may be used for NIH related funding archiving, not the PDF file of the published article. Publisher will not provide any pdf file of published article to NIH or authors.
|WARRANTIES AND COPYRIGHTS: By submitting
the manuscript, the authors warrant that the entire work is original and
unpublished; it is submitted only to this Journal and all text, data,
figures/tables or other illustrations included in the research article
are completely original and unpublished, and these have not been
previously published or submitted elsewhere in any form or media
whatsoever. All authors are responsible for the complete contents of
their manuscript. The author(s) warrant that the work contains no
unlawful or libelous statements and opinions and liable materials of any
kind whatsoever, do not infringe on any copyrights, intellectual
property rights, personal rights or rights of any kind of others, and
does not contains any plagiarized, fraudulent, improperly attributed
materials, instructions, procedures, information or ideas that might
cause any harm, damage, injury, losses or costs of any kind to person or
property. Each author(s) agrees to defend, indemnify, and hold harmless
American Scientific Publishers and the Editors for any breach of such
warranties. It is authors' responsibility to obtain written copyright
permissions from other sources (publishers) for reproduction of any
figures, tables, photos, illustrations, text or other copyright
materials from previously published work. It is the policy of American
Scientific Publishers to own the copyright of all contributions it
publishes. To comply with the U.S. Copyright Law, a Copyright Transfer
Form that transfer copyright of the article to the publisher must be
completed by the authors prior to publication of an accepted article in
this journal. Authors must submit a signed copy of the Copyright
Transfer Agreement with their manuscripts.
ETHICAL ISSUES: Authors cannot submit a manuscript for publication to other journals simultaneously. It is waste of valuable resources because editors and referees spent a great deal of time processing submitted manuscripts. It is also unethical to republish similar research articles (text/figures/tables) again because journals have limited page space and it most likely violates copyrights which have already been transferred to the first journal. Therefore, all journals require a signed author's copyright transfer agreement stating the originality of the research work submitted through a manuscript. As stated above that authors should submit original, new and unpublished research work to the journal. The ethical issues such as plagiarism, fraudulent and duplicate publication, violation of copyrights, authorship and conflict of interest are serious issues concerning ethical integrity when submitting a manuscript to a journal for publication.
WITHDRAWAL OF MANUSCRIPTS: If the author requests withdrawal of manuscript after submission within the time span when the manuscript is still in the peer-reviewing process with Editors/Referees, author is allowed to withdraw the manuscript without paying any withdrawal penalty whatsoever. However, it is unethical to withdraw a submitted manuscript from one journal if accepted by another journal. The withdrawal of manuscripts from the journals after submitting to the publisher will incur a withdrawal penalty from American Scientific Publishers. After the manuscript is accepted for publication either through journal editors or guest editors or conference organizers, the withdrawal is not permitted by American Scientific Publishers. If the authors or conference organizers or a third party withdraw manuscripts any time after final manuscripts have already been submitted to American Scientific Publishers for processing, the request is not entertained without a significant withdrawal penalty. Authors or conference organizers or a third party are not allowed to withdraw submitted manuscripts because the withdrawal wastes valuable manuscript processing time, money and works invested by the publisher. The authors or conference organizers or a third party must always pay $200 per page manuscript processing charges as withdrawal penalty to the publisher even if the withdrawal is permitted. The withdrawal of the conference papers by conference organizers will never be permitted and the conference organizers will be punished for withdrawal by paying a withdrawal penalty of US$500 per manuscript. Withdrawal of manuscripts is only allowed after withdrawal penalty has been fully paid to the American Scientific Publishers by the authors or conference organizers or a third party. Any reason whatsoever of withdrawal of submitted manuscripts is treated as invalid and completely unacceptable under any circumstances. Publisher is not responsible for any damages whatsoever resulting from this consequence of the author's or conference organizer's or a third party decision. All questions or differences whatsoever concerning manuscripts withdrawal from American Scientific Publishers whether as to construction or otherwise, shall be held in the County of Los Angeles, California, United States of America.
WARRANTIES FOR CONFERENCE ORGANIZERS: The Conference Organizer(s) submitting manuscripts to American Scientific Publishers warrant and represent that any material prepared by the Author(s) for the Journal shall be 100% new, original and unpublished in any form, shall not infringe upon or violate any copyright, trademark, obligation of confidentiality or other right or the privacy of others, or contain any libelous or unlawful statements or material or instructions that may cause harm or injury to a person or property; and that he/she will not include in the Journal any Article that the Editor believes or has any reason to believe may infringe or violate such rights or contain such material or matter or instructions that may cause harm or injury.
The Conference Organizer(s) submitting manuscripts to American Scientific Publishers represent and warrant that they have full power and authority to enter into this agreement. The Conference Organizer(s) agree to indemnify and hold the Publisher and any of its representatives harmless from any and all claims, demands, for any special, indirect, incidental, consequential or punitive damages of any kind whatsoever, including, but not limited to all liabilities, lost opportunities, costs, charges and expenses (including counsel fees) that the Publisher incurs or sustains arising out of any breach by the Conference Organizer(s) of the foregoing warranties and representations. The Conference Organizer(s) hereby agrees to indemnify and defend American Scientific Publishers from claims, costs, charges, damages, fees, expenses or liabilities of any kind whatsoever brought or preferred by any third party against Publisher.
The relationship between the parties is that of independent contractors and does not constitute a partnership and the Conference Organizer(s) shall have no authority to bind American Scientific Publishers in any way. All questions or differences whatsoever which may at any time hereafter arise between the parties hereto concerning this Agreement or the subject matter thereof and whether as to construction or otherwise, shall be held in the County of Los Angeles, California. These terms and conditions shall be construed and interpreted under the laws of the State of California.